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Chemotherapy-increased antineoplastic effects of antibody-toxin conjugates
Cancer Treatment Reports
|April 1, 1984
Abstract:
A model, employing murine L1210 leukemia to which the artificial determinant TNP was bound in vitro and an anti-DNP antibody-ricin A-chain conjugate, was used to explore the in vivo therapeutic potential of combined immunotoxin-chemotherapy treatment. Under conditions in which immunotoxin and chemotherapy as single therapies had only marginal therapeutic activity, their combined use was markedly effective.