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Updated: Feb 16, 2026

Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy
Published on: June 18, 2020
Hepatic cholesterol in lead nitrate induced liver hyperplasia
Abstract:
Wistar rats treated with lead nitrate were used in these experiments to provide evidence of the possible correlation between hyperplasia, induced cholesterol synthesis and the levels of glucose-6-phosphate dehydrogenase (G-6-PD) in the liver. Lead treatment increases liver weight, hepatic cholesterol esters and the relative content of free cholesterol. An increase of the incorporation of tritiated water in free and cholesterol esters was also observed. The effect of lead resulted in an increase of hepatic G-6-PD at all times considered. The correlation between these parameters and hyperplasia are discussed.
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