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Related Experiment Videos

Carboxyhemoglobin levels in banked blood.

W S Aronow, W J O'Donohue, J Freygang

    Chest
    |May 1, 1984
    PubMed
    Summary

    Nearly half of banked blood samples exceed air quality standards for carboxyhemoglobin. High carboxyhemoglobin levels in banked blood may pose risks for patients needing multiple transfusions, especially those with heart or lung conditions.

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    Area of Science:

    • Transfusion Medicine
    • Blood Banking
    • Environmental Health

    Background:

    • Carboxyhemoglobin (COHb) is a compound formed when hemoglobin binds with carbon monoxide.
    • Elevated COHb levels in banked blood may be a concern for transfusion recipients.
    • Air Quality Standards provide a benchmark for acceptable COHb levels.

    Purpose of the Study:

    • To determine the prevalence of carboxyhemoglobin levels exceeding 1.5% in banked blood.
    • To assess the proportion of banked blood with COHb levels of 2.0% or higher.

    Main Methods:

    • Analysis of carboxyhemoglobin levels in 101 randomly selected banked blood samples.
    • Comparison of measured COHb levels against established Air Quality Standards.

    Main Results:

    • 49% of banked blood samples had COHb levels greater than 1.5%.
    • 36% of samples exhibited COHb levels of 2.0% or more.
    • A significant prevalence of elevated COHb was observed in banked blood.

    Conclusions:

    • Banked blood frequently exceeds recommended carboxyhemoglobin limits.
    • High COHb blood may be unsuitable for patients requiring multiple transfusions, particularly those with cardiopulmonary disease.
    • Labeling banked blood for COHb content is recommended to guide transfusion practices.

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