Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vitamin D status after total gastrectomy.

K Kozawa, M Imawari, H Shimazu

    Digestive Diseases and Sciences
    |May 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Nosocomial infection with rotavirus vaccine strain in paediatric patients with immunodeficiency.

    The Journal of hospital infection·2021
    Same author

    Inhibition of plasmin attenuates murine acute graft-versus-host disease mortality by suppressing the matrix metalloproteinase-9-dependent inflammatory cytokine storm and effector cell trafficking.

    Leukemia·2014
    Same author

    Effects of interferon-α-transduced tumor cell vaccines and blockade of programmed cell death-1 on the growth of established tumors.

    Cancer gene therapy·2012
    Same author

    Lymphotropic hepatitis C virus has an interferon-resistant phenotype.

    Journal of viral hepatitis·2012
    Same author

    Measurement of HCV-Specific CD8(+) Cytotoxic T-Cell Activities in the Peripheral Blood by Europium Release Assay.

    Methods in molecular medicine·2011
    Same author

    Effects of bosentan on the skin lesions: an observational study from a single center in Japan.

    Rheumatology international·2008

    Total gastrectomy impacts vitamin D metabolism, causing lower 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D but higher 1,25-dihydroxyvitamin D. This suggests impaired vitamin D storage and increased action post-surgery.

    Area of Science:

    • Endocrinology
    • Gastroenterology
    • Nutritional Science

    Background:

    • Total gastrectomy significantly alters digestive physiology.
    • Vitamin D metabolism is crucial for calcium homeostasis and bone health.
    • Post-surgical changes can lead to nutrient deficiencies and metabolic disturbances.

    Purpose of the Study:

    • To investigate vitamin D status in patients following total gastrectomy.
    • To compare vitamin D metabolite levels and related markers between different surgical reconstructions.
    • To understand the interplay between vitamin D, parathyroid hormone, and calcium metabolism after gastrectomy.

    Main Methods:

    • Serum levels of 25-hydroxyvitamin D, 24,25-dihydroxyvitamin D, and 1,25-dihydroxyvitamin D were measured.
    • Immunoreactive parathyroid hormone and alkaline phosphatase levels were assessed.

    Related Experiment Videos

  • Urinary excretion of nephrogenous cyclic AMP was analyzed.
  • Patients were grouped based on two types of post-gastrectomy reconstruction.

    • Main Results:

    • Significantly decreased serum 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D levels were observed.
    • Serum 1,25-dihydroxyvitamin D levels were significantly increased.
    • Increased serum alkaline phosphatase and urinary nephrogenous cyclic AMP indicated enhanced vitamin D action.
    • No significant difference in vitamin D status was found between the two reconstruction types.

    Conclusions:

    • Patients after total gastrectomy exhibit defective vitamin D storage and enhanced vitamin D action.
    • Enhanced vitamin D action may be a compensatory mechanism for calcium deficiency.
    • Surgical reconstruction type did not substantially affect vitamin D status.