Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Piperazinylpyrazines with central serotoninmimetic activity.

W C Lumma, R D Hartman, W S Saari

    Journal of Medicinal Chemistry
    |June 1, 1978
    PubMed
    Summary

    Researchers synthesized novel piperazinyl pyrazines to investigate their serotonin-like activity. The compound 6-chloro-2(1-piperazinyl)pyrazine demonstrated potent central serotoninmimetic effects with minimal peripheral action.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Fixed drug eruption and generalized bullous fixed drug eruption: Insights from an analysis of the FDA Adverse Event Reporting System.

    The journal of allergy and clinical immunology. In practice·2024
    Same author

    Diagnostic accuracy of skin lesions amongst plastic surgeons and a dermatologist.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2017
    Same author

    Computer-aided surgical planning in the treatment of soft-tissue sarcoma.

    Annals of the Royal College of Surgeons of England·2010
    Same author

    Methyl aminolaevulinate-photodynamic therapy for actinic keratoses, squamous cell carcinoma in situ and superficial basal cell carcinoma employing a square wave intense pulsed light device for photoactivation.

    The British journal of dermatology·2009
    Same author

    Labial Morphology of Belonolaimus longicaudatus as Revealed by the Scanning Electron Microscope.

    Journal of nematology·2009
    Same author

    Two semi-automatic elutriators for extracting nematodes and certain fungi from soil.

    Journal of nematology·2009

    Area of Science:

    • Medicinal Chemistry
    • Neuropharmacology
    • Serotonin Receptor Research

    Background:

    • Serotonin (5-HT) is a key neurotransmitter regulating mood, cognition, and numerous physiological processes.
    • Dysregulation of serotonergic pathways is implicated in various central nervous system disorders.
    • Development of selective serotonin receptor modulators is a significant area of pharmaceutical research.

    Purpose of the Study:

    • To synthesize and characterize a novel series of 2-(1-piperazinyl)pyrazine derivatives.
    • To evaluate the synthesized compounds for their potential as central serotonin-mimetic agents.
    • To identify structure-activity relationships influencing central versus peripheral serotonin activity.

    Main Methods:

    • Chemical synthesis of a library of 2-(1-piperazinyl)pyrazine compounds.

    Related Experiment Videos

  • Pharmacological screening to assess serotonin-like activity in vitro and in vivo.
  • Comparative analysis of central and peripheral serotonin receptor interactions.

    • Main Results:

    • Successful synthesis of the target piperazinyl pyrazine series.
    • Compound 6-chloro-2-(1-piperazinyl)pyrazine (3a) exhibited potent central serotoninmimetic properties.
    • Compound 3a displayed significantly weaker peripheral serotoninmimetic activity compared to its central effects.

    Conclusions:

    • The 2-(1-piperazinyl)pyrazine scaffold is a promising structural motif for developing central serotonin-mimetic drugs.
    • Compound 3a represents a potential lead compound for further investigation in neurological and psychiatric disorders.
    • The study highlights the potential for selective targeting of central serotonin pathways.