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Related Experiment Videos

Toxic megacolon associated with methotrexate therapy.

L D Atherton, E S Leib, M D Kaye

    Gastroenterology
    |June 1, 1984
    PubMed
    Summary

    Methotrexate treatment for psoriasis can cause severe colitis, a rare complication. This prolonged gastrointestinal issue resolved with conservative care, unlike other methotrexate toxicities.

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    Area of Science:

    • Gastroenterology
    • Dermatology
    • Toxicology

    Background:

    • Psoriasis is a chronic autoimmune skin condition.
    • Methotrexate is a common immunosuppressive therapy for psoriasis.
    • Drug-induced colitis is a known but uncommon adverse effect of methotrexate.

    Observation:

    • A patient with psoriasis developed severe colitis and toxic megacolon during methotrexate therapy.
    • The colitis duration significantly exceeded other methotrexate-related toxicities like bone marrow depression, jaundice, and renal failure.
    • Colitis symptoms resolved with conservative management.

    Findings:

    • Methotrexate-induced colitis can be a prolonged and severe manifestation of drug toxicity.
    • Relative sparing of the distal colon may be a characteristic feature.
    • This case highlights a rare but significant adverse event associated with methotrexate use.

    Implications:

    • Clinicians should consider methotrexate toxicity in patients with psoriasis presenting with severe colitis.
    • Early recognition and conservative management are crucial for resolving methotrexate-induced colitis.
    • Further research into the mechanisms and management of this rare complication is warranted.

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