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Hepatotoxicity associated with maprotiline therapy: case report
The Journal of Clinical Psychiatry
|April 1, 1984
Summary
Maprotiline therapy for depression may cause elevated liver enzymes. Discontinuing the medication led to a normalization of these liver enzyme levels in a patient case.
Area of Science:
- Hepatology
- Clinical Pharmacology
- Psychiatry
Background:
- Hepatotoxicity is a potential adverse effect of antidepressant medications.
- Maprotiline is a tetracyclic antidepressant used for treating depression.
Observation:
- A cachectic, anicteric patient on maprotiline therapy presented with markedly elevated liver enzymes.
- Viral hepatitis was ruled out as a cause for the liver enzyme elevation.
Findings:
- Maprotiline therapy was associated with a significant increase in serum liver enzyme levels.
- Liver enzymes normalized shortly after the cessation of maprotiline treatment.
Implications:
- This case highlights the importance of monitoring liver function in patients receiving maprotiline.
- Clinicians should consider drug-induced liver injury when elevated liver enzymes are observed during maprotiline treatment.
- Further investigation into the hepatotoxic potential of maprotiline may be warranted.