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Related Experiment Videos

Hepatotoxicity associated with maprotiline therapy: case report.

R J Moldawsky

    The Journal of Clinical Psychiatry
    |April 1, 1984
    PubMed
    Summary

    Maprotiline therapy for depression may cause elevated liver enzymes. Discontinuing the medication led to a normalization of these liver enzyme levels in a patient case.

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    Area of Science:

    • Hepatology
    • Clinical Pharmacology
    • Psychiatry

    Background:

    • Hepatotoxicity is a potential adverse effect of antidepressant medications.
    • Maprotiline is a tetracyclic antidepressant used for treating depression.

    Observation:

    • A cachectic, anicteric patient on maprotiline therapy presented with markedly elevated liver enzymes.
    • Viral hepatitis was ruled out as a cause for the liver enzyme elevation.

    Findings:

    • Maprotiline therapy was associated with a significant increase in serum liver enzyme levels.
    • Liver enzymes normalized shortly after the cessation of maprotiline treatment.

    Implications:

    • This case highlights the importance of monitoring liver function in patients receiving maprotiline.
    • Clinicians should consider drug-induced liver injury when elevated liver enzymes are observed during maprotiline treatment.
    • Further investigation into the hepatotoxic potential of maprotiline may be warranted.

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