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Related Experiment Videos

Mania induced by metoclopramide: case report.

K S Ritchie, S H Preskorn

    The Journal of Clinical Psychiatry
    |April 1, 1984
    PubMed
    Summary

    A patient developed mania while taking metoclopramide, a drug affecting neurotransmitters. Symptoms reappeared upon rechallenge, indicating a drug-induced manic episode.

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    Area of Science:

    • Neuroscience
    • Psychiatry
    • Pharmacology

    Background:

    • Metoclopramide is a dopamine antagonist used for gastrointestinal and neurological disorders.
    • Neurotransmitter system dysregulation is implicated in mood disorders like mania.

    Observation:

    • A patient developed acute manic symptoms during metoclopramide treatment.
    • Symptoms ceased during a placebo period.
    • Manic symptoms reappeared upon metoclopramide rechallenge.

    Findings:

    • The case suggests metoclopramide can induce manic episodes in susceptible individuals.
    • Amitriptyline treatment appeared to mitigate the manic response.

    Implications:

    • This case highlights the potential for metoclopramide to trigger mania.
    • Clinicians should consider psychiatric side effects when prescribing metoclopramide.
    • Further research into metoclopramide's neuropsychiatric effects is warranted.

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