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Published on: November 4, 2010

Prognostic factors predicting control of chronic asthma symptoms in children receiving prophylactic bronchodilator

E Ekwo, J O Kim, L Dusdieker

    Journal of Chronic Diseases
    |January 1, 1984
    PubMed

    Insights

    Asthma symptom control improved over time with bronchodilator therapy. However, a history of exacerbations due to fear, dust, or cold stimuli predicted poorer asthma symptom control in children.

    Area of Science:

    • Pediatric Pulmonology
    • Allergy and Immunology

    Background:

    • Chronic asthma affects a significant number of children.
    • Effective management of pediatric asthma requires understanding predictive factors for treatment success.
    • Prophylactic bronchodilator therapy is a common treatment approach.

    Purpose of the Study:

    • To identify factors that predict the control of asthma symptoms in children undergoing chronic prophylactic bronchodilator therapy.
    • To evaluate the impact of specific stimuli (fear, dust, cold) on asthma symptom control over time.

    Main Methods:

    • A cohort of 312 children with chronic asthma receiving prophylactic bronchodilator therapy was studied.
    • Asthma symptom control was assessed over an 18-month period.
    • Statistical analysis was used to determine the association between patient history and symptom control.

    Main Results:

    • Asthma symptoms were controlled in 74.4% of patients after 18 months.
    • A history of symptom exacerbation by fear stimulus was associated with an 83.3% lower rate of control (p=0.0001).
    • A history of symptom exacerbation by dust (35.4%, p=0.003) or cold foods/drinks (71.4%, p=0.002) also predicted lower control rates.

    Conclusions:

    • The duration of therapy positively influences asthma symptom control.
    • Specific triggers like fear, dust, and cold are significant predictors of poorer asthma control in children.
    • Airway lability to certain stimuli plays a crucial role in predicting treatment outcomes for pediatric asthma.

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