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Microbial contamination of pharmaceutical injections at the site of administration
Journal of Clinical and Hospital Pharmacy
|March 1, 1984
Abstract:
The administration of a subcutaneous injection was simulated by piercing the skin of volunteers with syringe needles. Interiors of 2.4% of the needles were found to be contaminated with micro-organisms from the skin as were 3.8% of the exterior surfaces.
Insights
Subcutaneous injections carry a risk of microbial contamination. Study found skin microorganisms on 2.4% of needle interiors and 3.8% of exteriors during simulated injections.
Area of Science:
- Microbiology
- Infectious Diseases
- Medical Device Contamination
Background:
- Subcutaneous injections are common medical procedures.
- Sterility of injection equipment is crucial for patient safety.
- Potential for microbial transfer from skin to injection equipment exists.
Purpose of the Study:
- To quantify microbial contamination on syringe needles after simulated subcutaneous injections.
- To assess the risk of microorganism transfer from skin to needle interiors and exteriors.
Main Methods:
- Simulated subcutaneous injections were performed on volunteers using standard syringe needles.
- Needles were examined for microbial contamination on both interior and exterior surfaces post-procedure.
Main Results:
- Microbial contamination was detected on 2.4% of the interior needle surfaces.
- Microbial contamination was detected on 3.8% of the exterior needle surfaces.
Conclusions:
- Syringe needles can become contaminated with skin microorganisms during subcutaneous injection.
- A small but significant percentage of needles show contamination, highlighting potential risks.
- Adherence to aseptic techniques is critical to minimize microbial transfer during injections.