Retention data for antibiotics commonly used for bovine infections
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Abstract:
This study was designed to observe the maximum time that various antibiotics used in different ways as treatment of bovine infections persisted in milk after final treatment. Both Delvotest-P and Bacillus stearothermophilus (Difco) disc assay procedures were utilized for detection of antibiotic preparations used for treatment of mastitis. None persisted in milk longer than specified on their respective labels. Because antibiotic residues were detected in milk consequent to treatment for intrauterine infections, guidelines for withholding times following intrauterine treatment should be established.
Insights
Antibiotic residues in bovine milk were studied. Most antibiotics cleared by label-specified times, but intrauterine treatments require updated milk withdrawal guidelines to prevent residues.
Area of Science:
- Veterinary Pharmacology
- Food Safety
- Animal Health
Background:
- Antibiotic use in cattle is crucial for treating infections like mastitis.
- Ensuring milk safety requires understanding antibiotic persistence post-treatment.
- Intrauterine antibiotic treatments present unique residue concerns.
Purpose of the Study:
- To determine the milk residue persistence of various antibiotics used in bovine treatment.
- To evaluate adherence to label-specified withdrawal times.
- To assess the need for revised guidelines for intrauterine antibiotic treatments.
Main Methods:
- Utilized Delvotest-P and Bacillus stearothermophilus disc assay for antibiotic detection.
- Monitored milk samples following different antibiotic administration routes.
- Compared detected residue levels against manufacturer-provided withholding times.
Main Results:
- No tested antibiotics persisted in milk beyond their labeled withdrawal periods.
- Antibiotic residues were detected in milk following intrauterine infection treatments.
- Current label guidelines may not adequately address intrauterine treatment residue risks.
Conclusions:
- Standard antibiotic treatments for bovine mastitis generally comply with withdrawal times.
- Intrauterine antibiotic administration necessitates specific residue monitoring and guideline development.
- Establishing clear withholding times for intrauterine treatments is essential for milk safety.