[Blood coagulation and fibrinolysis in spontaneous delivery]

Differences in blood coagulating and fibrinolytic abilities before and after delivery were investigated in order to elucidate the changes occurring at the delivery time in increased blood coagulation and inhibited fibrinolytic condition during pregnancy, especially in its latter period, and the relation between the amount of intrapartum hemorrhage and blood coagulating and fibrinolysis before delivery was examined in order to predict hemorrhage. Twenty-one women who had no complications in pregnancy or delivery and gave birth by vaginal spontaneous delivery with not more than 500ml of intrapartum hemorrhage (normal hemorrhage group) and 7 women who gave birth by vaginal spontaneous delivery with not less than 501ml of abnormal intrapartum hemorrhage (abnormal hemorrhage group) were used as the objects of study, and coagulating and fibrinolytic abilities were examined. The result obtained are summarized as follows: Differences in blood coagulating and fibrinolytic abilities before and after delivery tended to be similar in both normal and abnormal hemorrhage groups. Platelet count and fibrinogen content were decreased, activated partial thromboplastin time became shorter, compared with those examined before delivery, and these appeared to be an increase in blood coagulating ability after delivery. Fibrinolytic ability was seen to be not remarkably different before and after delivery. Fibrinolytic ability was seen to be not remarkably different before and after delivery. Platelet ADP and epinephrine aggregation were reduced after delivery, but platelet collagen aggregation showed no change. As for blood coagulating and fibrinolytic abilities before delivery, prothrombin time was shorter in the abnormal hemorrhage group than in the normal hemorrhage group.(ABSTRACT TRUNCATED AT 250 WORDS)