[Analysis of high risk factors in endometrial carcinoma--endocrine imbalances and dysfunctional uteri]

We analysed the high risk factors in endometrial adenocarcinoma by using androgen sterilized Sprague-Dawley rats (ASR). The results obtained were as follow: The response of uterine weight and uterine peroxidase induction by E2 administration in neonatal ASR was less than in normal control rats (NR). The mean cytosol E2 receptor content in the uteri in 300- and 550-day-old ASR was less than in NR. The plasma progesterone (P) values for ASR at 100, 300 and 750 days of age were significantly lower than the values for NR. The values for E1, E2 at 300 and 750 days of age were not significantly different between ASR and NR. Therefore, the plasma E1 + E2: P ratios in the ASR were almost 3 times greater than in NR. The plasma E1 : P and E2 : P ratios in 300-day-old ASR were twice as great as in NR. E2 : P in 550-day-old ASR with adenocarcinoma was 2.5 times and 4.6 times greater than in ASR without adenocarcinoma and NR, respectively. The present results suggested that endocrine imbalance (continuous estrogenic stimulation unopposed by P) and a dysfunctional uterus of long duration were the high risk factors in endometrial adenocarcinoma in ASR.