[Study on follow-up procedure for postmolar patients]

Since 1974, in Chiba prefecture patients with trophoblastic disease have been registered with the Department of Obstetrics and Gynecology, Chiba University School of Medicine as the registration and management center. An original follow-up system for postmolar patients has been used and following results obtained. From 1974 to 1981 (8 years), 1544 hydatidiform mole patients were registered. The number of deliveries was 582,641. The incidence of hydatidiform mole in deliveries was 1:377. Postmolar patients whose hCG titers were greater than 10,000 IU/l, 1,000 IU/l and 100 IU/l at the fifth, eighth and twelfth week respectively, were treated as trophoblastic sequelae. In these check points, 155 cases (10.0%) were treated as sequelae, namely, 9 cases (0.6%) of choriocarcinoma, 54 cases (3.5%) of invasive mole and 94 cases undetermined (6.1%). At the fifth week after molar evacuation, there were 96 cases whose hCG titers were from 1,000 to 10,000 IU/l, and at the eight week, 86 cases were from 100 to 1,000 IU/l. Among the former there were 30 cases (31.2%) and among the latter, 36 cases (41.9%) of spontaneous remission. By using this follow-up system, 66 cases (36.3%) were able to avoid over treatment.