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Related Experiment Videos

Chloramphenicol ototoxicity. A case report.

S M Iqbal, C B Srivatsav

    The Journal of Laryngology and Otology
    |May 1, 1984
    PubMed
    Summary

    This case report highlights rare instances of profound sensorineural hearing loss caused by chloramphenicol. Repeated drug exposure led to progressive hearing loss in both ears, suggesting an allergic reaction.

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    Area of Science:

    • Ototoxicology
    • Pharmacology
    • Neuroscience

    Background:

    • Chloramphenicol, a broad-spectrum antibiotic, is known for potential toxic side effects.
    • Sensorineural hearing loss is a serious adverse effect that can occur with certain medications.
    • Understanding drug-induced ototoxicity is crucial for patient safety.

    Observation:

    • A patient developed bilateral profound sensorineural hearing loss.
    • The hearing loss was progressive, initially affecting one ear.
    • A second course of chloramphenicol administration led to involvement of the other ear.

    Findings:

    • The case suggests an idiosyncratic or allergic response to chloramphenicol as the cause of ototoxicity.
    • Repeated exposure to chloramphenicol was linked to the development of bilateral hearing impairment.
    • This highlights a rare but severe adverse drug reaction.

    Implications:

    • Clinicians should exercise caution when prescribing chloramphenicol, especially for repeated courses.
    • Patients receiving chloramphenicol require vigilant monitoring for potential auditory toxicity.
    • Early detection and intervention are critical to manage drug-induced hearing loss.

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