Related Experiment Video
Updated: Aug 2, 2026

Adult Mouse Digit Amputation and Regeneration: A Simple Model to Investigate Mammalian Blastema Formation and Intramembranous Ossification
Published on: July 12, 2019
Morphogenesis of the amphibian limb blastema: the relationship between pattern and form
Abstract:
A relationship between pattern formation and field shape is established following the formation of rounded blastemas on lower arm limb stumps after treatment with vitamin A. Pattern formation is not affected by alteration in blastemal shape caused by removal of the dermis from the thigh region of the leg. We conclude, therefore, that blastemal shape does not play a causal role in establishing limb pattern. Data relating the number of cells present between the cardinal axial poles of blastemas and the size of blastemas is discussed in terms of short are intercalation and short range cell-cell interactions during pattern regulation.
Related Concept Videos
Cleavage and Blastulation
Gastrulation
Determination
Morphogenesis
Zygotic Development And Stem Cell Formation
Changes in the Appendicular Skeleton with Age
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...

