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Related Experiment Videos

Intramuscular injection-site complications.

D J Greenblatt, M D Allen

    JAMA
    |August 11, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Intramuscular (IM) injections are common in hospitalized patients, with local complications occurring infrequently. However, certain drugs like cephalothin sodium require reevaluation for IM use due to higher complication rates.

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    Area of Science:

    • Pharmacovigilance
    • Drug Safety
    • Clinical Pharmacology

    Background:

    • Intramuscular (IM) injections are a frequent route of drug administration in hospitalized patients.
    • Understanding the incidence and nature of local complications associated with IM injections is crucial for patient safety.

    Purpose of the Study:

    • To assess the frequency of intramuscular injections among hospitalized medical patients.
    • To identify drugs commonly administered via IM route.
    • To determine the incidence and types of local complications associated with IM injections and specific drugs.

    Main Methods:

    • Analysis of data from the Boston Collaborative Drug Surveillance Program.
    • Inclusion of 26,294 hospitalized medical patients.
    • Identification of drugs with >80% IM administration and documentation of local injection site complications.

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    Main Results:

    • 46% of patients received at least one IM injection.
    • Local complications were reported in only 48 patients (0.4% of IM recipients).
    • Cephalothin sodium was most frequently associated with local complications.

    Conclusions:

    • Clinically significant local complications from IM injections are uncommon overall.
    • Certain drugs, notably cephalothin sodium, are associated with a relatively high frequency of injection-site complications.
    • The clinical utility of IM administration for drugs causing frequent local reactions warrants reevaluation.