Abnormal fibrinolysis: the cause of lipodermatosclerosis or "chronic cellulitis" in patients with primary lymphedema

Blood fibrinolytic activity was measured in 20 patients with primary lymphedema, ten without and ten with skin changes usually attributed to "chronic cellulitis". The patients with abnormal skin showed reduced fibrinolytic activity, a finding previously described in patients with chronic venous disease and lipodermatosclerosis . It is postulated that changes of "chronic cellulitis" are identical to lipodermatosclerosis and are produced by a similar mechanism, namely reduced fibrinolysis.