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Related Experiment Videos

Evidence of rebound effect with ascorbic acid.

C S Tsao, S L Salimi

    Medical Hypotheses
    |March 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    High intake of ascorbic acid (vitamin C) temporarily increases urinary excretion. Upon reduction, excretion drops below baseline, suggesting induced metabolic changes and potential value in ascorbic acid metabolites.

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    Area of Science:

    • Biochemistry
    • Human Physiology
    • Nutritional Science

    Background:

    • Ascorbic acid (vitamin C) is an essential nutrient with various physiological roles.
    • High-dose vitamin C supplementation is common, but its long-term effects on excretion patterns require further understanding.

    Purpose of the Study:

    • To investigate the urinary excretion pattern of ascorbic acid in individuals after a period of high intake followed by a reduced intake.
    • To explore potential metabolic adaptations induced by high ascorbic acid consumption.

    Main Methods:

    • Two subjects received 10 g of ascorbic acid daily, followed by 125 mg daily.
    • 24-hour urine samples were collected and analyzed for ascorbic acid concentration over 40 days.

    Main Results:

    Related Experiment Videos

    • Mean urinary ascorbic acid excretion during high intake was approximately 2 g/day.
    • Excretion returned to baseline levels within 6 days of reducing intake.
    • Urinary ascorbic acid levels dropped below baseline for 10-12 days post-reduction, indicating a potential depletion or altered metabolism.

    Conclusions:

    • High ascorbic acid intake may induce enzymatic changes leading to increased metabolism of vitamin C.
    • The observed sub-baseline excretion suggests a potential depletion or a shift in ascorbic acid utilization.
    • Further research is warranted to elucidate the physiological actions of ascorbic acid metabolites.