[Effects of a natural estrogen, estradiol, on hemostasis in guinea pigs]

17-beta-estradiol was administered weekly to female guinea-pigs at the dosage of 2-3 mg/kg body weight during 4-6 weeks. Compared to a control population, no significant effect was observed on: recalcification time; thromboelastography; PTT; APTT; Quick one stage prothrombin time; antigenic and active plasma fibrinogen level; antithrombin III level; factor XI level; red and white blood cell count. A significant increase in levels of factor II (+25%), of factor V, of factor XII (+40%) and a decrease in levels of complex VII + X was observed. Values for AT III, factor XII, chronometric and immunologic fibrinogen plasma levels, unknown until now for the guinea-pig, were established.