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Development of posterior subcapsular cataracts in asthmatic children

R G Bhagat, H Chai

    Pediatrics
    |May 1, 1984
    PubMed

    Insights

    Asthmatic children on long-term steroid therapy face a higher risk of developing posterior subcapsular cataracts (PSCC). Markedly delayed bone age alongside steroid use exceeding two years are key indicators for PSCC risk in these children.

    Area of Science:

    • Ophthalmology
    • Pediatrics
    • Endocrinology

    Background:

    • Posterior subcapsular cataracts (PSCC) are a known complication of systemic corticosteroid therapy.
    • Identifying children with asthma at risk for PSCC is crucial for proactive management.

    Purpose of the Study:

    • To evaluate factors associated with systemic steroid administration that may influence PSCC development in asthmatic children.
    • To identify specific risk factors for PSCC in pediatric asthma patients undergoing steroid treatment.

    Main Methods:

    • Retrospective evaluation of 40 asthmatic children receiving systemic steroids.
    • Assessment of steroid duration, dose, frequency of bursts, bone age retardation, and mode of administration.
    • Correlation of these factors with the presence or absence of PSCC.

    Main Results:

    • Seven out of 40 (17.5%) asthmatic children developed PSCC.
    • All children with PSCC had received steroids for at least two years and exhibited markedly delayed bone age.
    • The combination of prolonged steroid use (≥2 years) and markedly delayed bone age was strongly associated with PSCC development.

    Conclusions:

    • Asthmatic children on systemic steroids for two years or longer with markedly delayed bone age are at significantly increased risk for PSCC.
    • Duration of steroid therapy and bone age retardation are critical predictors for PSCC in this pediatric population.

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