Cholinergic activation of medial preoptic area by amygdala for ovulation in rat

Ovulation blocked by amygdalar lesion was restored by carbachol injection into medial preoptic area (mPOA) in rats on the afternoon of proestrus. Both spontaneous and carbachol-induced ovulation was blocked by application of nicotinic and muscarinic cholinergic antagonists (mecamylamine and atropine) to mPOA. The effect was more pronounced in the latter case. The study suggests amygdalar facilitatory control of ovulation to be mediated via mPOA through the involvement of cholinergic mechanisms.