Effects of acrylonitrile on tissue glutathione concentrations in rat, mouse, and hamster

Glutathione (GSH) is implicated in acrylonitrile (ACN) detoxification. To add to the understanding of ACN detoxification we studied the effects of ACN on GSH levels in various tissues and species. GSH in four tissues (brain, lung, liver, and kidney) from three species (rat, mouse and hamster) were assessed at five time points subsequent to ACN treatment. ACN-induced decreases in GSH were most pronounced in the rat and occurred in all four tissues and were less pronounced in mouse and hamster tissues. Liver GSH was most effected in all species.