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[Rhythm of the daily changes in functions in ischemic heart disease]

I E Oranskiĭ, G P Seliverstova, T V Krupina

    Kardiologiia
    |June 1, 1978
    PubMed

    Insights

    Patients with ischemic heart disease exhibit altered daily rhythms in cardiovascular and brain function, with shifted activity peaks. This suggests biological clocks are sensitive to disease-related physiological changes.

    Area of Science:

    • Cardiology
    • Chronobiology
    • Neuroscience

    Background:

    • Ischemic heart disease (IHD) impacts cardiovascular and brain function.
    • Daily (circadian) rhythms are crucial for physiological regulation.
    • Understanding rhythm alterations in IHD is vital for patient management.

    Purpose of the Study:

    • To investigate daily variations in cardiovascular, brain, metabolic, and hemostasis indices in IHD patients.
    • To compare these rhythms with those of healthy individuals.
    • To assess the sensitivity of biological clocks in IHD.

    Main Methods:

    • Studied 162 IHD patients.
    • Monitored daily changes in cardiovascular system function.
    • Analyzed bioelectric brain activity, hemodynamics, lipid metabolism, electrolytes, 17-oxogenic steroids (17-OCS), and hemostasis indices.

    Main Results:

    • IHD patients showed reduced daily rhythm amplitude and delayed peak activity compared to healthy individuals.
    • Daily excretion of 17-OCS and aldosterone had similar amplitudes but a 4-hour delay.
    • Significant alterations in daily rhythms were observed across multiple physiological systems.

    Conclusions:

    • Biological clocks in IHD patients are sensitive to altered physiological conditions.
    • Circadian rhythm disruptions are a key feature of ischemic heart disease.
    • Further research into chronotherapy for IHD may be warranted.

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