[Effect of pure sound and vibration on the embryonic development of the mouse]

Studies were conducted about the effects of noise and vibration on the ontogenesis of mouse. Application of noise and vibration was carried out in 340 female mice in the phenocritical phase. The parameters of pure sound were 100 dB and 10.000 Hz. The vibration was carried out with the oscillating velocity of 87,1 mm/s and the oscillating acceleration of 3,45 X 10(4) mm/s2. The duration of noise was 10 hours, of vibration 4 and 8 hours. In an other experiment the animals were exposed to the combination of noise (10 h) and vibration (4 h). 581 fetuses were evaluated by subsequent parameters: Fetal length and weight, placental diameter, resorptions and haematomas. It was concluded that retardations, resorptions and haematomas were results from noise and vibration exposure. A teratogenic effect of these noxes was not evident. Probable the noxes evoked stress reactions in the female animals. Subsequently a constriction of blood vessels impairs the placental function.