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Increased central cornea thickness in systemic sclerosis.

L Serup, J Serup, H K Hagdrup

    Acta Ophthalmologica
    |February 1, 1984
    PubMed
    Summary
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    Central cornea thickness (CCT) is significantly increased in patients with systemic sclerosis. This finding suggests CCT measurement could aid in diagnosing and monitoring systemic sclerosis.

    Area of Science:

    • Ophthalmology
    • Rheumatology
    • Medical Diagnostics

    Background:

    • Systemic sclerosis is an autoimmune disease affecting connective tissues.
    • Ocular manifestations of systemic sclerosis are not fully understood.
    • Central cornea thickness (CCT) is a measurable ocular parameter.

    Purpose of the Study:

    • To investigate central cornea thickness (CCT) in patients with systemic sclerosis.
    • To compare CCT in systemic sclerosis patients with healthy controls.
    • To assess the relationship between CCT and disease duration or treatment.

    Main Methods:

    • Central cornea thickness (CCT) measured using a Haag-Streit pachymeter.
    • Study included 32 patients with systemic sclerosis and 29 age- and sex-matched healthy controls.

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  • Statistical analysis compared CCT between groups and correlated it with disease duration.

    • Main Results:

    • Patients with systemic sclerosis exhibited significantly increased CCT compared to controls (P < 0.001).
    • Elevated CCT was observed in 69-72% of systemic sclerosis patients.
    • CCT increased with disease duration up to 8 years, then plateaued; no increase observed with collagen inhibitor treatment.

    Conclusions:

    • Central cornea thickness (CCT) is significantly elevated in systemic sclerosis.
    • CCT may serve as a supplementary quantitative tool for systemic sclerosis diagnosis and monitoring.
    • Further research could explore the clinical utility of CCT in managing systemic sclerosis.