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Evaluation of proteinuria.

D W Stewart, J A Gordon, A C Schoolwerth

    American Family Physician
    |April 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Proteinuria, or excess urinary protein, can signal serious kidney disease or be insignificant. Persistent proteinuria requires further investigation to determine its cause and clinical importance.

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    Area of Science:

    • Nephrology
    • Clinical Chemistry

    Background:

    • Proteinuria can be an early indicator of significant kidney disease.
    • Abnormal urinary protein excretion is defined as over 150 mg per 24 hours in adults.
    • The origin of proteinuria can be glomerular, tubular, or overflow.

    Purpose of the Study:

    • To differentiate the clinical significance of proteinuria.
    • To outline methods for investigating the source of urinary protein.

    Main Methods:

    • Comparing dipstick and sulfosalicylic acid tests to identify protein source.
    • Utilizing electrophoresis for confirmatory diagnosis.

    Main Results:

    • Transient and intermittent proteinuria typically lack clinical importance.

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  • Persistent proteinuria necessitates further medical evaluation.

    • Conclusions:

    • Determining the source and persistence of proteinuria is crucial for clinical management.
    • Prompt investigation of persistent proteinuria aids in early diagnosis and treatment of renal disease.