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Keratitis in relapsing polychondritis.

A Matoba, S Plager, J Barber

    Annals of Ophthalmology
    |April 1, 1984
    PubMed
    Summary
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    Relapsing polychondritis (RP) can manifest with peripheral ulcerative keratitis, a rare eye condition. Early diagnosis and treatment with dapsone can effectively manage both ocular and systemic symptoms of this inflammatory disease.

    Area of Science:

    • Ophthalmology
    • Rheumatology
    • Immunology

    Background:

    • Relapsing polychondritis (RP) is a rare, systemic autoimmune disease characterized by progressive cartilage destruction.
    • Ocular manifestations of RP, such as peripheral ulcerative keratitis, can lead to significant vision loss if not managed promptly.

    Observation:

    • An 11-year-old girl presented with peripheral corneal thinning and superficial pannus, initially without systemic signs.
    • Over two years, she developed auricular inflammation, nasal cartilage collapse, and polyarthritis, leading to a diagnosis of relapsing polychondritis.
    • The patient experienced a spontaneous ocular perforation due to peripheral ulcerative keratitis, requiring surgical repair.

    Findings:

    • Treatment with dapsone, a nonsteroidal anti-inflammatory drug, induced remission of both the ocular and systemic manifestations of relapsing polychondritis.

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  • This case highlights the potential for RP to present initially with isolated ocular findings.

    • Implications:

    • Early recognition of ocular signs in RP is crucial for timely intervention and prevention of severe complications.
    • Dapsone appears to be an effective therapeutic option for managing ocular and systemic symptoms in relapsing polychondritis.
    • Further research into the pathogenesis and optimal treatment strategies for RP-associated ocular disease is warranted.