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Determinants and importance of atrial pressure morphology in atrial septal defect
Insights
Prominent right atrial "v" waves are less common in adults with atrial septal defects (ASDs) than in children. In adults, this finding is linked to higher heart pressures and may decrease with age.
Area of Science:
- Cardiology
- Pediatric Cardiology
- Hemodynamics
Background:
- Prominent
- "v" waves in jugular vein and right atrial pressure tracings are a recognized sign of atrial septal defect (ASD).
- The prevalence, age-related patterns, and hemodynamic factors influencing the
- "v" greater than or equal to
- "a" wave configuration in ASDs remain understudied.
Purpose of the Study:
- To assess the sensitivity and specificity of the
- "v" greater than or equal to
- "a" wave configuration as a hemodynamic sign of isolated secundum atrial septal defect.
- To investigate the age-related and hemodynamic determinants of this
- "v" greater than or equal to
- "a" wave pattern in both pediatric and adult populations.
Main Methods:
- Analysis of pressure recordings from 15 adults and 80 children with isolated secundum ASDs in sinus rhythm.
- Comparison with pressure recordings from 40 adults and 55 children in sinus rhythm without structural heart abnormalities or with coronary/valvular heart disease.
- Evaluation of the
- "v" greater than or equal to
- "a" wave configuration's diagnostic accuracy for ASDs.
Main Results:
- Only 20% of adults with ASDs exhibited prominent right atrial
- "v" waves compared to 63% of children, though specificity was high for both groups.
- In adults,
- "left atrialization" of the right atrium (
- "v" greater than or equal to
- "a") was associated with younger age and higher right atrial/ventricular end-diastolic pressures.
- In contrast, children showed no age or hemodynamic determinants for this pattern; older adults and children with ASDs often displayed
- "right atrialization" of the left atrial wave (
- "a" greater than
- "v").
Conclusions:
- Adults with ASDs rarely exhibit prominent right atrial
- "v" waves compared to children.
- In adults, the presence of prominent right atrial
- "v" waves correlates with higher left atrial and right heart pressures, potentially due to increased systolic transatrial flow.
- The diminished prevalence of prominent
- "v" waves in older adults may stem from age-related changes in right ventricular compliance.
Abstract:
A prominent "v" wave relative to the "a" wave in the jugular vein and right atrial pressure tracing is considered to be a common haemodynamic sign of atrial septal defect. Since the prevalence, age relation, and haemodynamic determinants of the "v" greater than or equal to "a" wave configuration have not been studied the pressure recordings from 15 adults and 80 children with an isolated secundum atrial septal defect in sinus rhythm and from 40 adults and 55 children in sinus rhythm without structural cardiac abnormalities or with coronary and valvular heart disease were studied to assess the sensitivity and specificity of the "v" greater than or equal to "a" wave configuration in atrial septal defect. Only 20% of adults with an atrial septal defect had prominent right atrial "v" waves compared with 63% of children, although the specificity was quite high for each group. In adults "left atrialisation " of the right atrium ("v" greater than or equal to "a" wave) occurred in younger patients with higher right atrial and right ventricular end diastolic pressures. In contrast, in children no age related or haemodynamic determinants for the "v" greater than or equal to "a" pattern were found. In addition, most adults but few children with an atrial septal defect had "right atrialisation " of the left atrial wave configuration ("a" greater than "v"). This was found in older adults with lower right atrial and right ventricular end diastolic pressures and in older children with larger left to right shunts. Thus in contrast to children adults with an atrial septal defect rarely show a prominent "v" wave in the right atrium. The presence of a prominent right atrial "v" wave in adults with an atrial septal defect is associated with relatively higher left atrial and right heart pressures than is the absence of this sign and may be related to relatively higher systolic transatrial flow in these patients. The relative paucity of prominent right atrial "v" waves in older adults suggest that the systolic phase flow may diminish with age, possibly from progressive alteration in compliance of the chronically dilated right ventricle.