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Related Experiment Videos

Increased forearm vascular resistance after dopamine blockade.

D Mannering, E D Bennett, N Mehta

    British Journal of Clinical Pharmacology
    |April 1, 1984
    PubMed
    Summary

    Domperidone, a dopamine antagonist, was studied for its effects on blood flow. Systemic administration decreased forearm blood flow and increased vascular resistance, suggesting a central mechanism rather than a direct local effect.

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    Area of Science:

    • Pharmacology
    • Cardiovascular Physiology

    Background:

    • Domperidone is a dopamine antagonist.
    • Peripheral hemodynamic effects require investigation.

    Purpose of the Study:

    • To investigate the peripheral hemodynamic effects of domperidone.
    • To determine if domperidone's effects are mediated centrally or locally.

    Main Methods:

    • Administered 40 mg intravenous domperidone to 10 normal subjects.
    • Infused domperidone directly into the brachial artery in four subjects.
    • Measured forearm blood flow and calculated forearm vascular resistance.
    • Assessed effects on peripheral sympathetic tone using passive leg elevation.

    Main Results:

    • Systemic domperidone significantly decreased forearm blood flow by 9% and increased forearm vascular resistance by 11%.

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  • Direct brachial artery infusion of domperidone caused no measurable changes in forearm blood flow.
  • Domperidone administration reduced the sympathetic response to passive leg elevation.

    • Conclusions:

    • Domperidone's effect on increasing peripheral vascular tone is unlikely mediated by direct local action.
    • The drug's influence on peripheral vascular tone is suggested to be via a central control mechanism.