[Permeability of bilayer lipid membranes to amphotericin B]

The permeability coefficient of BLM to amphotericin B decreases as cholesterol content of the membrane and KCl concentration of the aqueous medium increases. This effect is supposed to be the result of significant growth of BLM microviscosity caused by sharp increase of BLM half-pores content. The data obtained show the biological effect of amphotericin B to the "two-sided" one. To account for the lack of the polyene effect on the anion permeability of biological membranes the hypothesis is suggested that half-pores and pores are not formed in these membranes.