[Cerebrosides as one of the factors regulating the functional state of the blood-vascular wall system]

During 4 months rats were given intraperitoneal injections of cerebrosides in a dose of 5 mg/kg bw. The measurements were taken of the arterial blood pressure and the function of blood cells. It has been demonstrated that as compared to the control, the experimental animals showed a significant elevation of the blood pressure, hyperaggregation of platelets and red cells, an increase in the ability of platelets to adhesion. It has been also disclosed that there was a decrease in the time of the occurrence of muscle fatigue and death under stress induced by forced dynamic work. The data obtained are of interest in the aspect of investigating the role played by glycolipids in the pathogenesis of cardiovascular diseases.