[High-resolution electrophoresis in a new polyacrylamide-gel block]

A new gel block for electrophoretic separation is offered. When viewed frontally, the block has a form of a trapezium. During electrophoresis a gradient of voltage is formed in such a block, as a result of which the mobility of macromolecules to be separated markedly decreases. The combination of the block with polyacrylamide gel gradient makes it possible to raise the resolving power of electrophoresis up to 300-400 dalton. The new gel block can be applied successfully to the performance of fine biochemical assays and molecular-biological studies of proteins, glycoproteins and nucleic acids.