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Apatite associated destructive arthritis.

P A Dieppe, M Doherty, D G Macfarlane

    British Journal of Rheumatology
    |May 1, 1984
    PubMed
    Summary
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    This study describes a unique destructive arthropathy in elderly patients, characterized by joint pain, effusions, and rapid bone/cartilage loss. Apatite crystals in synovial fluid suggest a potential role in this large-joint atrophy.

    Area of Science:

    • Rheumatology
    • Orthopedics
    • Crystal Arthropathies

    Background:

    • Destructive arthropathy can significantly impact elderly patients.
    • Distinctive joint pathologies require thorough characterization for effective management.

    Purpose of the Study:

    • To describe a specific type of destructive arthropathy observed in elderly individuals.
    • To investigate the clinical, radiographic, and synovial fluid characteristics of this condition.
    • To explore potential etiological factors, including crystal deposition.

    Main Methods:

    • Descriptive case series of twelve patients (11 women, 1 man, aged 66-83).
    • Clinical assessment of joint symptoms, effusions, and instability.
    • Radiographic analysis of bone and cartilage changes.

    Related Experiment Videos

  • Synovial fluid analysis for cell counts and crystal identification (apatite).
  • Synovial biopsy in four patients to examine calcific material.

    • Main Results:

    • Predominant involvement of shoulders and knees.
    • Clinical presentation included pain, large effusions, instability, and rapid progression.
    • Radiographs revealed bone and cartilage attrition with minimal repair.
    • Synovial fluid showed low cell counts and positive staining for apatite crystals.
    • Synovium contained extensive calcific material; seven patients had radiographic evidence.

    Conclusions:

    • A characteristic form of large-joint atrophy can occur in elderly patients.
    • Apatite crystal deposition may play a role in the pathogenesis of this arthropathy.
    • This condition can manifest across various joint sites and clinical contexts in older adults.