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Related Experiment Videos

Polyamines in breast cancer.

A N Kingsnorth, H M Wallace, N J Bundred

    The British Journal of Surgery
    |May 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    High polyamine levels in breast cancer indicate aggressive tumors. Spermidine and spermine levels predict early recurrence, serving as a crucial prognostic marker independent of node status.

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    Fitoterapia·2014

    Area of Science:

    • Oncology
    • Biochemistry

    Background:

    • Polyamines (putrescine, spermidine, spermine) are crucial for cell growth.
    • Their role in breast cancer prognosis requires further investigation.

    Purpose of the Study:

    • To evaluate polyamine levels as prognostic indicators in breast cancer.
    • To correlate polyamine concentrations with tumor aggressiveness and recurrence.

    Main Methods:

    • Quantification of putrescine, spermidine, and spermine in 54 breast cancer tumors.
    • Analysis of polyamine levels in relation to histological grade, receptor status, tumor stage, and recurrence.

    Main Results:

    • Elevated polyamine levels correlated with higher histological grade (III) and estrogen-receptor negative status.

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  • Advanced T4 tumors and medullary carcinomas showed increased polyamine concentrations.
  • Higher spermidine and spermine levels were significantly associated with recurrence within 2 years post-mastectomy.
  • Tumor size and node status did not influence primary tumor polyamine levels.

    • Conclusions:

    • Breast cancer polyamine levels serve as a biological marker for tumor aggressiveness.
    • These polyamine levels are independent prognostic indicators of early tumor recurrence, even beyond node status.