Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Age-related decrease in apomorphine modulation of acetylcholine release from rat striatal slices.

J M Thompson, C L Makino, J R Whitaker

    Brain Research
    |May 7, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Ear, nose and throat manifestations of leishmaniasis: Case series from a tertiary centre in the United Kingdom.

    Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·2023
    Same author

    Optical Control of Magnetic Feshbach Resonances by Closed-Channel Electromagnetically Induced Transparency.

    Physical review letters·2016
    Same author

    Shear Viscosity of a Unitary Fermi Gas Near the Superfluid Phase Transition.

    Physical review letters·2015
    Same author

    Anomalous minimum in the shear viscosity of a Fermi gas.

    Physical review letters·2014
    Same author

    Observation of conformal symmetry breaking and scale invariance in expanding Fermi gases.

    Physical review letters·2014
    Same author

    Age-Related Neostriatal Alterations in the Rat: Failure of L-DOPA to Alter Behavior.

    Neurobiology of aging·2013
    Same journal

    Targeting neurodevelopmental miR132-3p promotes neuroprotection and axon regeneration after optic nerve injury in mice.

    Brain research·2026
    Same journal

    Variability in acoustic startle response and prepulse inhibition across adulthood in Fragile X messenger ribonucleoprotein 1 knockout mice.

    Brain research·2026
    Same journal

    Transcriptome-guided modeling reveals insulin-related metabolic dysfunction in SCA3 mouse cerebellum.

    Brain research·2026
    Same journal

    Intranasal stromal cell-derived factor-1α mitigates parkinsonian deficits via dual modulation of neuroinflammation and gut microbiota in MPTP-induced models.

    Brain research·2026
    Same journal

    Emotions, the amygdala, and the right hemisphere.

    Brain research·2026
    Same journal

    Electroacupuncture treatment enhances hippocampal growth hormone level and restores mitochondrial function in vascular dementia rats.

    Brain research·2026
    See all related articles

    Aging Wistar rats show reduced basal acetylcholine release and accumulation. Senescent rats exhibit a failure of apomorphine to inhibit KCl-induced release, indicating dopaminergic dysfunction linked to motor decline.

    Area of Science:

    • Neuroscience
    • Aging Research
    • Neurochemistry

    Background:

    • Acetylcholine (ACh) plays a crucial role in motor control and cognitive functions.
    • Age-related changes in neurotransmitter systems, particularly dopaminergic pathways, are implicated in motor deficits.
    • Striatal function is vital for regulating motor behavior.

    Purpose of the Study:

    • To investigate age-related changes in acetylcholine release in the rat striatum.
    • To examine the impact of senescence on dopaminergic modulation of acetylcholine release.
    • To correlate neurochemical changes with motor-behavioral decline in aging rats.

    Main Methods:

    • Assessment of basal and stimulated [3H]acetylcholine ([3H]ACh) release in striatal slices from Wistar rats of different ages (8, 12, and 24 months).

    Related Experiment Videos

  • Measurement of [3H]ACh accumulation.
  • Evaluation of apomorphine's effect on KCl-induced [3H]ACh release in senescent animals.

    • Main Results:

    • A significant age-related decline in basal [3H]ACh release was observed.
    • This decline in release was correlated with reduced [3H]ACh accumulation.
    • Senescent rats (24 months) showed a complete failure of apomorphine to inhibit KCl-induced [3H]ACh release.

    Conclusions:

    • Striatal dopaminergic receptor alterations in senescence contribute to impaired striatal function.
    • These neurochemical changes are associated with a decline in motor-behavioral function.
    • The findings highlight the impact of aging on cholinergic and dopaminergic systems in the striatum.