Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Kainic-acid-induced seizures: a developmental study.

B J Albala, S L Moshé, R Okada

    Brain Research
    |March 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Prediction of major complications after hepatectomy using liver stiffness values determined by magnetic resonance elastography.

    The British journal of surgery·2018
    Same author

    A genome-wide association study of coping behaviors suggests FBXO45 is associated with emotional expression.

    Genes, brain, and behavior·2018
    Same author

    Molecular and morphological analyses revealed a cryptic species of dojo loach Misgurnus anguillicaudatus (Cypriniformes: Cobitidae) in Japan.

    Journal of fish biology·2017
    Same author

    Lower risk of progression from prediabetes to diabetes with health checkup with lifestyle education: Japan Ningen Dock study.

    Nutrition, metabolism, and cardiovascular diseases : NMCD·2017
    Same author

    Biological characteristics of staphylococcal enterotoxin Q and its potential risk for food poisoning.

    Journal of applied microbiology·2017
    Same author

    Upper-normal waist circumference is a risk marker for metabolic syndrome in normal-weight subjects.

    Nutrition, metabolism, and cardiovascular diseases : NMCD·2015

    Kainic acid-induced seizures in rats show pups have lower seizure thresholds and higher mortality. The substantia nigra

    Area of Science:

    • Neuroscience
    • Developmental Biology
    • Pharmacology

    Background:

    • Kainic acid is a potent neurotoxin that can induce seizures.
    • Seizure susceptibility and manifestations can vary with age.
    • The substantia nigra plays a role in seizure modification in adult animals.

    Purpose of the Study:

    • To investigate developmental differences in kainic acid-induced seizures in rats.
    • To compare seizure severity, mortality, and brain activity across different age groups.
    • To explore the role of the substantia nigra in age-dependent seizure susceptibility.

    Main Methods:

    • Rats of three age groups (pups, pubescents, adults) were administered kainic acid.
    • Behavioral seizure manifestations and mortality were recorded.

    Related Experiment Videos

  • Deoxyglucose (DG) autoradiography was used to assess brain activity, specifically in the substantia nigra.

    • Main Results:

    • All age groups exhibited seizures, but pups showed distinct behaviors, lower convulsive thresholds, higher severity, and increased mortality.
    • Necrotic lesions were observed in adults and pubescents but not in pups.
    • DG uptake in the substantia nigra increased in adults and pubescents, but not in pups.

    Conclusions:

    • Developmental stage significantly influences kainic acid-induced seizure outcomes in rats.
    • The lack of substantia nigra involvement in pups may contribute to their increased seizure severity and early generalization.
    • These findings highlight the developing substantia nigra's role in seizure modulation.