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Related Experiment Videos

Nonshivering thermogenesis.

J Himms-Hagen

    Brain Research Bulletin
    |February 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Nonshivering thermogenesis, primarily in brown adipose tissue, is regulated by sympathetic nervous activity. This process is influenced by cold, diet, and photoperiod, impacting energy balance and thermoregulation across species.

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    Area of Science:

    • Neuroscience
    • Metabolic Physiology
    • Endocrinology

    Background:

    • Nonshivering thermogenesis (NST) is a cold-induced heat production independent of muscle shivering.
    • Recent research identifies brown adipose tissue (BAT) as the primary site for NST, regulated by sympathetic nervous system (SNS) activity.
    • Diet-induced thermogenesis (DIT) in BAT is also stimulated by food intake, influencing BAT mass and thermogenic capacity.

    Purpose of the Study:

    • To explore the neural regulation of thermogenesis in brown adipose tissue (BAT).
    • To understand the roles of cold, diet, and photoperiod as stimuli for BAT activity and growth.
    • To compare neural control mechanisms of thermogenesis in different species, including hibernators and non-hibernators.

    Main Methods:

    • Review of existing research on NST and DIT in BAT.

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  • Analysis of sympathetic nervous system control over BAT.
  • Comparative study of neural regulation in species like hamsters and mice, considering hibernation and torpor.

    • Main Results:

    • BAT mass and thermogenic capacity are adaptable to cold and dietary stimuli.
    • Photoperiod influences BAT growth/regression in hibernators.
    • Neural regulation of BAT involves central control for thermoregulation and energy balance, with species-specific variations.

    Conclusions:

    • Neural regulation of BAT thermogenesis is integral to both thermoregulation and energy balance.
    • Specific hypothalamic regions (ventromedial hypothalamus) are crucial for DIT but not cold-induced NST.
    • Comparative studies are essential for developing accurate neural models of BAT thermogenesis, as mechanisms vary significantly between species.