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Candida parapsilosis fungemia in burn patients: report of three cases
Abstract:
Three patients with Candida parapsilosis septicemia, secondary to large burns, are reported. All patients sustained large burns with inhalation injuries and were treated with various topical antibiotics. All had sepsis with various bacterial organisms and had received treatment with systemic antibiotics prior to the development of the Candida episode. Once a positive blood culture for Candida parapsilosis was obtained, treatment was carried out with amphotericin-B. Sensitivity data indicated that this was the appropriate systemic agent. All patients recovered uneventfully after a 10-day course of amphotericin-B therapy.
Insights
Severe burn patients with Candida parapsilosis septicemia successfully recovered after amphotericin-B treatment. This antifungal therapy proved effective for bloodstream infections in burn victims.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Burn Critical Care
Background:
- Large burns and inhalation injuries predispose patients to severe infections.
- Bacterial sepsis is common in burn patients, often treated with systemic antibiotics.
- Candida parapsilosis septicemia can be a secondary complication in critically ill burn patients.
Observation:
- Three burn patients developed Candida parapsilosis septicemia after initial bacterial sepsis and antibiotic treatment.
- Blood cultures confirmed Candida parapsilosis as the causative agent.
- Antifungal susceptibility testing guided the selection of amphotericin-B.
Findings:
- Systemic amphotericin-B therapy was initiated upon diagnosis of Candida parapsilosis septicemia.
- All three patients received a 10-day course of amphotericin-B.
- Sensitivity data confirmed amphotericin-B as an appropriate agent for these infections.
Implications:
- Amphotericin-B is an effective treatment for Candida parapsilosis septicemia in severe burn patients.
- Early diagnosis and appropriate antifungal therapy are crucial for favorable outcomes.
- Burn care protocols should consider the risk of secondary fungal infections.