Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cardiac arrest following protamine administration.

F Chung, J Miles

    Canadian Anaesthetists' Society Journal
    |May 1, 1984
    PubMed
    Summary

    A rare case of fatal cardiac arrest after protamine reversal of heparin during vascular surgery is reported. Patients with prior protamine exposure or fish allergies face higher risks, necessitating alternative heparin reversal methods.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Anaesthesia and analgesia for total knee arthroplasty.

    BJA education·2026
    Same author

    Robotic Total Hip Arthroplasty in Atypical Hip Anatomy: Accuracy of Component Positioning and Clinical Outcomes in 192 Complex Cases.

    The Journal of arthroplasty·2026
    Same author

    Medicine in the drone age: prehospital emergency care under the threat of enemy UAS.

    BMJ military health·2025
    Same author

    Prenatal cortisol exposure impairs adrenal function but not glucose metabolism in adult sheep.

    The Journal of endocrinology·2023
    Same author

    A new oral model of free fatty acid kinetics to assess lipolysis in subjects with and without type 2 diabetes.

    American journal of physiology. Endocrinology and metabolism·2023
    Same author

    Postoperative outcomes in surgical patients with obstructive sleep apnoea diagnosed by sleep studies: a meta-analysis and trial sequential analysis.

    Anaesthesia·2022

    Area of Science:

    • Cardiovascular Surgery
    • Anesthesiology
    • Pharmacology

    Background:

    • Heparin is a common anticoagulant used during vascular surgery.
    • Protamine sulfate is the standard agent for reversing heparin's effects.
    • Reactions to protamine can lead to severe cardiovascular complications.

    Observation:

    • This case report details a fatal cardiac arrest immediately following protamine administration.
    • Risk factors for protamine reactions include prior exposure to protamine (e.g., in insulin preparations) and fish allergies.
    • Protamine-induced hypotension may result from immunological or non-immunological pathways.

    Findings:

    • Protamine reversal of heparinization can precipitate life-threatening cardiac events.
    • Specific patient populations exhibit increased susceptibility to adverse protamine reactions.
    • The mechanisms underlying protamine-induced hypotension are complex and multifactorial.

    Implications:

    • Vigilance is crucial when administering protamine, especially in at-risk patients.
    • Exploring and implementing alternative heparin reversal strategies is warranted.
    • This case underscores the importance of risk assessment and preparedness for protamine reactions in surgical settings.

    Related Experiment Videos