Proliferative Brenner tumor or ovarian metastases? A case report

A case of low-grade superficial transitional papillomas of the urinary bladder and concomitant bilateral ovarian tumors with close similarities to the rare proliferative Brenner tumor is reported. Due to lack of benign Brenner elements, metastases from the bladder tumors were suggested. Death was apparently related to the effect of chemotherapy, and metastases were never confirmed. In review of the case, the authors found that the morphologic appearances and biological behavior of the ovarian tumors were more consistent with a proliferative Brenner tumor than with metastases. It is pointed out that a proliferative Brenner tumor should not be excluded in the absence of benign Brenner elements when other features are characteristic. Bilateral proliferating Brenner tumors are probably not reported previously. Histogenetic implications of a combined proliferative complex of bladder papillomas and Brenner tumor are briefly discussed.