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Cytogenetic study in multiple myeloma.

A Ferti, A Panani, G Arapakis

    Cancer Genetics and Cytogenetics
    |July 1, 1984
    PubMed
    Summary
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    Cytogenetic analysis of ten multiple myeloma (MM) patients revealed chromosomal abnormalities in half of them. Marker chromosomes, including 14q+, trisomy 1q, and translocations, were frequently observed in these patients.

    Area of Science:

    • Hematology
    • Cytogenetics
    • Oncology

    Background:

    • Multiple myeloma (MM) is a hematologic malignancy characterized by uncontrolled proliferation of plasma cells.
    • Cytogenetic abnormalities are common in MM and are associated with prognosis and disease progression.

    Purpose of the Study:

    • To investigate the cytogenetic profile of multiple myeloma patients.
    • To identify common chromosomal abnormalities and marker chromosomes in MM.

    Main Methods:

    • G-banding technique was employed for cytogenetic analysis.
    • Ten patients diagnosed with multiple myeloma were included in the study.

    Main Results:

    • Five out of ten patients (50%) exhibited chromosomal abnormalities.

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  • Common findings included the 14q+ marker chromosome (3 cases), partial or complete trisomy for 1q (4 cases), and involvement of chromosome #6 (2 cases).
  • Specific translocations identified were t(11;14) in one case and t(2;8) in a patient with Bence Jones kappa MM.

    • Conclusions:

    • Cytogenetic analysis is crucial for understanding the heterogeneity of multiple myeloma.
    • Specific chromosomal abnormalities, such as 14q+ and trisomy 1q, are prevalent in MM and may serve as potential diagnostic or prognostic markers.