Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A multicenter clinical study of cefoperazone.

M Alix, V Arreza, S Brillantes

    Clinical Therapeutics
    |January 1, 1984
    PubMed
    Summary

    Cefoperazone demonstrated high efficacy in treating moderate to severe infections in both pediatric and adult patients in the Philippines. The antibiotic showed significant effectiveness, with over 85% of adults and 90% of children showing improvement.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Infectious bovine keratoconjunctivitis in dairy herds: Presence of haemolytic Moraxella bovis and Moraxella bovoculi.

    Research in veterinary science·2026
    Same author

    Strategic use of enzyme-linked immunosorbent assay as a complementary tool for the diagnosis of bovine tuberculosis.

    Research in veterinary science·2025
    Same author

    Risk factors associated with calf mortality from birth to weaning in pasture-based dairy herds in Argentina.

    Preventive veterinary medicine·2025
    Same author

    Psychosocial risk factors and perceived health of medical residents.

    Occupational medicine (Oxford, England)·2025
    Same author

    Evolution of evidence-based diagnostic criteria in adolescents with polycystic ovary syndrome.

    Human reproduction (Oxford, England)·2024
    Same author

    Standardization of radiograph readings during bowel management week.

    Pediatric surgery international·2023

    Area of Science:

    • Infectious Diseases
    • Pharmacology
    • Clinical Medicine

    Background:

    • Antibiotic resistance is a growing global concern, necessitating the evaluation of effective treatment options.
    • Cefoperazone is a third-generation cephalosporin antibiotic with broad-spectrum activity against various bacterial pathogens.
    • Limited data exists on the efficacy of cefoperazone in pediatric and adult populations within the Philippines.

    Purpose of the Study:

    • To evaluate the clinical efficacy and safety of cefoperazone in treating moderate to severe infections in adult and pediatric patients.
    • To assess the effectiveness of cefoperazone in patients previously treated with other antibiotic regimens.
    • To determine the correlation between isolated pathogens and clinical outcomes with cefoperazone treatment.

    Main Methods:

    Related Experiment Videos

    • A prospective study involving 35 adult and 11 pediatric patients across nine hospitals in the Philippines.
    • Patients received cefoperazone at dosages ranging from 1 to 8 gm/day for adults and 0.450 to 4 gm/day for children, divided into two doses.
    • Treatment duration varied from 5 to 30 days for adults and 5 to 11 days for children.

    Main Results:

    • Overall efficacy rates were 85.72% for adults and 90.90% for pediatric patients.
    • In patients switched to cefoperazone, efficacy rates were 85% for adults and 100% for pediatric patients.
    • Analysis of 26 isolated pathogens showed a 92.3% efficacy rate for cefoperazone.

    Conclusions:

    • Cefoperazone is an effective antibiotic for treating moderate to severe infections in both pediatric and adult populations in the Philippines.
    • The drug demonstrates high efficacy, particularly in patients who have not responded to or were switched from other antibiotic regimens.
    • Further studies with follow-up cultures are recommended to fully elucidate the pharmacokinetic and pharmacodynamic profiles of cefoperazone in this population.