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A multicenter clinical study of cefoperazone
Insights
Cefoperazone demonstrated high efficacy in treating moderate to severe infections in both pediatric and adult patients in the Philippines. The antibiotic showed significant effectiveness, with over 85% of adults and 90% of children showing improvement.
Area of Science:
- Infectious Diseases
- Pharmacology
- Clinical Medicine
Background:
- Antibiotic resistance is a growing global concern, necessitating the evaluation of effective treatment options.
- Cefoperazone is a third-generation cephalosporin antibiotic with broad-spectrum activity against various bacterial pathogens.
- Limited data exists on the efficacy of cefoperazone in pediatric and adult populations within the Philippines.
Purpose of the Study:
- To evaluate the clinical efficacy and safety of cefoperazone in treating moderate to severe infections in adult and pediatric patients.
- To assess the effectiveness of cefoperazone in patients previously treated with other antibiotic regimens.
- To determine the correlation between isolated pathogens and clinical outcomes with cefoperazone treatment.
Main Methods:
- A prospective study involving 35 adult and 11 pediatric patients across nine hospitals in the Philippines.
- Patients received cefoperazone at dosages ranging from 1 to 8 gm/day for adults and 0.450 to 4 gm/day for children, divided into two doses.
- Treatment duration varied from 5 to 30 days for adults and 5 to 11 days for children.
Main Results:
- Overall efficacy rates were 85.72% for adults and 90.90% for pediatric patients.
- In patients switched to cefoperazone, efficacy rates were 85% for adults and 100% for pediatric patients.
- Analysis of 26 isolated pathogens showed a 92.3% efficacy rate for cefoperazone.
Conclusions:
- Cefoperazone is an effective antibiotic for treating moderate to severe infections in both pediatric and adult populations in the Philippines.
- The drug demonstrates high efficacy, particularly in patients who have not responded to or were switched from other antibiotic regimens.
- Further studies with follow-up cultures are recommended to fully elucidate the pharmacokinetic and pharmacodynamic profiles of cefoperazone in this population.
Abstract:
Thirty-five adult and 11 pediatric patients in nine Philippine hospitals were treated with cefoperazone for various moderate to severe infections. Adults received 1 to 8 gm/day and children received 0.450 to 4 gm/day in two divided doses, for a mean period of eight to nine days (ranges, 5 to 11 days for children and 5 to 30 days for adults). The efficacy rate (cured and improved) was 90.90% for pediatric patients and 85.72% for adult patients. In a group of patients shifted from other antibiotic regimens, efficacy rates were 100% for pediatric patients and 85% for adult patients treated with cefoperazone. No follow-up cultures were obtained from patients from whom 26 pathogens were isolated, but correlations between the isolates and clinical efficacy showed that cefoperazone had an efficacy rate of 92.3%.