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Decrease of platelet serotonin content in ovariectomized female rats.

P Guicheney, D Marcel

    Endocrinology
    |June 1, 1984
    PubMed
    Summary
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    Ovariectomy in rats led to a 23% reduction in platelet serotonin (5-HT). This decrease in serotonin is not due to altered platelet uptake mechanisms but may involve ovarian hormone modulation of peripheral 5-HT metabolism.

    Area of Science:

    • Neuropharmacology
    • Endocrinology
    • Biochemistry

    Background:

    • Platelets play a role in serotonin (5-HT) transport and storage.
    • Ovarian hormones are known to influence various physiological processes, including neurotransmitter systems.

    Purpose of the Study:

    • To investigate the effect of ovariectomy on platelet serotonin concentration and uptake in rats.
    • To explore the potential role of ovarian hormones in modulating peripheral serotonin metabolism.

    Main Methods:

    • High-pressure liquid chromatography was used to quantify platelet serotonin levels.
    • Platelet-rich plasma was used to assess serotonin uptake kinetics (Km, Vmax) at different temperatures.
    • In vitro experiments assessed the impact of 17 beta-estradiol and progesterone on platelet serotonin uptake.

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    Main Results:

    • Ovariectomized rats exhibited a 23% decrease in platelet serotonin concentration compared to sham-operated controls.
    • The kinetic parameters (Km, Vmax) for serotonin uptake were not significantly different between the groups.
    • In vitro incubation with 17 beta-estradiol and progesterone did not alter serotonin uptake levels.

    Conclusions:

    • Ovarian hormone deficiency, induced by ovariectomy, is associated with reduced peripheral platelet serotonin levels.
    • The observed decrease in platelet serotonin is likely due to altered serotonin metabolism rather than a change in the platelet uptake mechanism.
    • Ovarian hormones may physiologically modulate peripheral serotonin metabolism independently of the platelet uptake system.