Related Experiment Videos
Cortisol and glucose tolerance in normal pregnancy.
Diabete & Metabolisme
|January 1, 1984
Summary
Pregnancy increases cortisol levels, potentially impairing glucose tolerance. This study found a correlation between higher cortisol and poorer glucose tolerance in pregnant individuals, suggesting cortisol
Area of Science:
- Endocrinology
- Reproductive Biology
- Metabolic Health
Background:
- Pregnancy is associated with significant hormonal changes.
- Cortisol levels naturally rise during gestation.
- Gestational diabetes mellitus (GDM) affects glucose metabolism during pregnancy.
Purpose of the Study:
- To investigate the relationship between elevated cortisol and impaired glucose tolerance in normal pregnancy.
- To examine the correlation between cortisol levels and insulin/glucagon secretion.
- To compare pregnancy findings with postpartum measurements.
Main Methods:
- Studied 17 normal pregnant women.
- Measured total and free plasma cortisol and urinary cortisol excretion monthly from week 12.
- Assessed glucose tolerance, insulin, and glucagon responses throughout pregnancy and postpartum.
Main Results:
- Cortisol levels (total, free plasma, urinary excretion) were elevated in early pregnancy and increased throughout gestation.
- Glucose tolerance deteriorated progressively during pregnancy.
- Significant positive correlations were found between increased cortisol levels/excretion and worsened glucose tolerance (r=0.55–0.63, p<0.05).
Conclusions:
- Elevated cortisol levels during pregnancy may contribute to the 'diabetogenicity' of pregnancy.
- No correlation was observed between cortisol changes and insulin/glucagon responses.
- Cortisol elevation is a potential factor in pregnancy-induced glucose intolerance.