Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Radiation-induced changes in the breast.

S J Schnitt, J L Connolly, J R Harris

    Human Pathology
    |June 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Reovirus receptors and apoptosis.

    Virology·2002
    Same author

    Fine-needle aspiration biopsy of nonpalpable breast lesions in a multicenter clinical trial: results from the radiologic diagnostic oncology group V.

    Radiology·2001
    Same author

    Reovirus binding to cell surface sialic acid potentiates virus-induced apoptosis.

    Journal of virology·2001
    Same author

    Pathologic features of breast cancers in women with previous benign breast disease.

    American journal of clinical pathology·2001
    Same author

    Junction adhesion molecule is a receptor for reovirus.

    Cell·2001
    Same author

    Diagnostic accuracy of 99mTc-sestamibi breast imaging: multicenter trial results.

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2001
    Same journal

    TRPS1 and GATA3 Expression in BRG1/SMARCA4-deficient Malignant Neoplasms.

    Human pathology·2026
    Same journal

    Clinicopathologic and Molecular Characteristics of Acral Melanomas Harboring RARA Fusions.

    Human pathology·2026
    Same journal

    Clinical Impact of Second Opinion Consultation in Bladder Biopsies and Transurethral Resection of Bladder Tumors.

    Human pathology·2026
    Same journal

    Prognostic relevance and molecular correlates of Claudin-1 expression in pancreatic neuroendocrine tumors.

    Human pathology·2026
    Same journal

    Mixed Phenotype Acute Leukemia: Lineage Assignment, Immunophenotypic Classification and Genetic Insights.

    Human pathology·2026
    Same journal

    Chronic myelomonocytic leukemia revisited: A comprehensive review with emphasis on the oligomonocytic subtype.

    Human pathology·2026
    See all related articles

    Therapeutic radiation for breast cancer causes atypical epithelial cells in the terminal duct lobular unit (TDLU). These radiation effects mimic new neoplasms but are distinct from them.

    Area of Science:

    • Oncology
    • Radiation Oncology
    • Pathology

    Background:

    • Breast cancer patients undergo radiation therapy, which can affect non-neoplastic breast tissue.
    • Post-treatment abnormalities necessitate distinguishing radiation effects from recurrent or new cancers.

    Purpose of the Study:

    • To define the effects of therapeutic ionizing radiation doses on residual non-neoplastic breast tissue.
    • To identify characteristic radiation-induced changes in breast tissue.
    • To differentiate radiation effects from neoplastic changes in post-treatment breast tissue.

    Main Methods:

    • Evaluation of 36 postirradiation breast tissue specimens from 30 breast cancer patients.
    • Comparison with 35 non-irradiated control breast tissue specimens.
    • Analysis of tissue sampled an average of 30.4 months post-therapy due to new abnormalities.

    Related Experiment Videos

    Main Results:

    • Characteristic radiation effects include atypical epithelial cells in the terminal duct lobular unit (TDLU) with lobular sclerosis and atrophy, present in all irradiated patients.
    • Radiation-induced changes varied in severity and extent, unrelated to dose, age, or adjuvant chemotherapy.
    • Radiation effects were distinguishable from carcinoma by the absence of cellular proliferation and preservation of cellular polarity.

    Conclusions:

    • Therapeutic radiation significantly alters non-neoplastic breast tissue, primarily within the TDLU.
    • Recognizing these radiation-induced changes is crucial for accurate diagnosis and avoiding misinterpretation as new or recurrent neoplasms.
    • Familiarity with radiation effects on breast tissue aids in clinical and mammographic assessments post-therapy.