Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyperlipidemia and premature arteriosclerosis.

F R Smith

    Lipids
    |May 1, 1978
    PubMed
    Summary

    Recent studies show that plasma lipoprotein levels, specifically low-density lipoprotein and high-density lipoprotein, are strongly linked to arteriosclerosis risk. Genetic lipid disorders also identify high-risk patient groups, advancing our understanding of heart disease.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A new forensic tool to date human blood pools.

    Scientific reports·2020
    Same author

    [The anatomy of the lung in regard to segmental extirpation].

    Revista mexicana de tuberculosis y enfermedades del aparato respiratorio·2014
    Same author

    Carcinoma of the vulva; results of treatment and effect of special factors on results.

    Surgery, gynecology & obstetrics·2010
    Same author

    Causes of and treatment options for abnormal scar tissue.

    Journal of wound care·2005
    Same author

    Transdermal drug delivery using electroporation. I. Factors influencing in vitro delivery of terazosin hydrochloride in hairless rats.

    Journal of pharmaceutical sciences·2000
    Same author

    Transdermal drug delivery using electroporation. II. Factors influencing skin reversibility in electroporative delivery of terazosin hydrochloride in hairless rats.

    Journal of pharmaceutical sciences·2000

    Area of Science:

    • Cardiovascular Science
    • Lipid Metabolism
    • Atherosclerosis Research

    Background:

    • Significant advancements in understanding plasma lipoprotein concentrations and arteriosclerosis over the past decade.
    • Epidemiologic studies confirm low-density lipoprotein (LDL) correlates directly, and high-density lipoprotein (HDL) inversely, with coronary disease risk.
    • Genetic hyperlipidemias highlight specific subpopulations at elevated risk.

    Purpose of the Study:

    • To synthesize current knowledge on the relationship between plasma lipoproteins and arteriosclerosis.
    • To investigate the role of genetic lipid disorders in cardiovascular risk.
    • To explore how cellular cholesterol metabolism is regulated by plasma lipoproteins.

    Main Methods:

    • Prospective and case-control epidemiologic studies in the general population.
    • Detailed studies of patients and families with genetic hyperlipidemias (hypercholesterolemia, hypertriglyceridemia).
    • Analysis of skin fibroblast lines from patients with genetic hyperlipidemias.

    Main Results:

    • Established direct correlation between LDL and coronary disease risk.
    • Established inverse correlation between HDL and coronary disease risk.
    • Identified subpopulations at particular risk due to genetic lipid disorders.
    • Provided new insights into cellular cholesterol metabolism regulation by lipoproteins.

    Conclusions:

    • Epidemiological and biochemical data increasingly support the hypothesis linking plasma lipids to atherosclerosis.
    • Understanding of lipoprotein metabolism and its role in cardiovascular disease has significantly improved.
    • Genetic studies offer crucial insights into personalized risk assessment for arteriosclerosis.

    Related Experiment Videos