Related Experiment Videos
A three-step synthesis of (+/-)-beta-methyleneaspartic acid
Abstract:
A simplified, three-step synthesis for (+/-)-beta- methyleneaspartic acid is described. Condensation of diethyl malonate with ethyl pyruvate gives 1,1,2- tricarbethoxyprop -1-ene, which is alpha-aminated with chloramine to give 1-amino-1,1,2- tricarbethoxyprop -2-ene. The latter is hydrolyzed in acid to give the title compound.