Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Allergic vasculitis caused by vitamin B6].

T Ruzicka, J Ring, O Braun-Falco

    Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
    |April 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Properly classifying skin changes. Exanthema--what is what?].

    MMW Fortschritte der Medizin·2001
    Same author

    [Symptomatic therapy of exanthema. Finding the proper externum].

    MMW Fortschritte der Medizin·2001
    Same author

    Once-daily desloratadine improves the signs and symptoms of chronic idiopathic urticaria: a randomized, double-blind, placebo-controlled study.

    International journal of dermatology·2001
    Same author

    Calcitriol 3 microg g-1 ointment in combination with ultraviolet B phototherapy for the treatment of plaque psoriasis: results of a comparative study.

    The British journal of dermatology·2001
    Same author

    Desloratadine in the treatment of chronic idiopathic urticaria.

    Allergy·2001
    Same author

    [Toxic epidermal necrolysis (drug-induced Lyell's syndrome). I. Clinical features and differential diagnosis].

    Deutsche medizinische Wochenschrift (1946)·2001

    A patient experienced severe skin lesions after taking pain relievers. Allergy tests revealed a reaction to vitamin B6, indicating drug-induced vasculitis.

    Area of Science:

    • Dermatology
    • Immunology
    • Pharmacology

    Background:

    • Analgesic preparations are commonly used for pain relief.
    • Adverse drug reactions can manifest in various dermatological conditions.
    • Vasculitis is an inflammation of blood vessel walls.

    Observation:

    • A patient presented with extensive bullous and hemorrhagic lesions on the lower legs.
    • Lesions appeared after the patient took over-the-counter analgesic medications.
    • Allergologic testing indicated an Arthus-type hypersensitivity reaction specifically to vitamin B6.

    Findings:

    • Histopathological examination of skin biopsies revealed superficial and deep vasculitis.
    • Immunofluorescence studies showed deposition of complement component 3 (C3) at the basement membrane of dermal venules.

    Related Experiment Videos

  • These findings suggest an immune complex-mediated vasculitis triggered by vitamin B6.

    • Implications:

    • Vitamin B6, even in over-the-counter analgesics, can trigger immune-mediated vasculitis in susceptible individuals.
    • Early identification of drug-induced vasculitis is crucial for effective patient management.
    • This case highlights the importance of comprehensive allergologic testing for unexplained dermatological reactions to medications.